| Ubong Ntewo | Author, Christian Leader |
| Uchiha Itachi | Ninja, Assassin (Character from Naruto, a highly skilled ninja and member of the Uchiha clan) |
| Uchiha Madara | Fictional character |
| Udayakumar D.S. | Author, Motivational Speaker |
| Ueda Akinari | Japanese Author, Poet, and Scholar |
| Ufuoma Apoki |
| Ujjwal Arora | Self-help Author |
| Ulonda Faye | Mindfulness Teacher |
| Umair Naeem | Author, Inspirational Speaker |
| Umberto Eco | Novelist, Philosopher, Semiotician, Best known for The Name of the Rose |
| Umesha Chathurangi Handapangoda | Writer |
| Unarine Ramaru | Author |
| Uncle Ben (Spider-Man) | Fictional Character (Uncle of Spider-Man, known for the phrase "With great power comes great responsibility") |
| Unknown |
| Unknown | (Refers to anonymous authors or sources, often used for traditional sayings or ancient texts) |
| Upamanyu Chatterjee | Author, Journalist |
| Upile Chisala | Author |
| Upton Sinclair | Writer, Activist |
| Urania Sarri | Author, Novelist |
| Uri Gatt Gutman | Writer, Philosopher |
| Ursula Andress | Actress, Model |
| Ursula Hegi | Author |
| Ursula K. Le Guin | Author (Known for science fiction and fantasy works, such as The Left Hand of Darkness and A Wizard of Earthsea) |
| Ursula K. LeGuin | Novelist, Fantasy and Science Fiction Writer |
| Ursula Parrott | Novelist |
| Ursule Molinaro | Novelist, Translator |
| Uruj Shahid | Author, Motivational Speaker |
| Urvashi Bundel | Author |
| Usain Bolt | Professional Sprinter (Olympic Gold Medalist) |
| Usinxki | Educator, Pedagogue (Konstantin Ushinsky, Russian educator known as the "father of Russian pedagogy, " influential in the development of modern education in Russia) |
| USMC | United States Marine Corps |
| Usopp | Pirate, Sniper (Character from One Piece, known for his marksmanship and tall tales) |
| Utanu Maa | Author |
| Utpal Vaishnav | Self-help Author |
| Uyen Nicole Duong | Author |
| Uyen Ninh | Social Commentator, Essayist |
| Uyliam Batơ Dit | Poet, Dramatist (Irish poet and playwright, a key figure in 20th-century literature, and a Nobel laureate in Literature) |
| Uzodinma Iweala | Novelist, Physician |
